Revolutionize Lyobead Production with Sphera Discovery
Introducing Sphera Discovery — an exciting advancement in lyobead technology! Today, BioDot explores how the Sphera Discovery can transform PCR reagents into lyobeads and the powerful benefits this can bring to your lab or business.
Whether you’re a lab scientist or a manager aiming to boost efficiency, you know the essential value of PCR master mixes that are:
· Stable
· Sensitive
· Reproducible
Developing PCR master mixes with these qualities often requires significant trial and error, costing time and resources.
Traditionally, PCR reagents are freeze-dried into a powder, sometimes referred to as a “lyocake.” Freeze-drying simplifies handling while preserving reagent properties.
By adapting this lyophilization process to individual liquid droplets, the Sphera Discovery creates “lyobeads” instead of a lyocake. Just like a lyocake, they can be stored in PCR tubes or directly integrated into microfluidic cartridges for automated diagnostics. And, best of all, lyobeads are an ideal format for point-of-care testing due to a variety of useful properties.
How Lyobeads Benefit Your Business
Lyophilized master mixes can stay stable for months or years in lyobead form, preserving enzyme activity and reagent integrity with minimal risk of contamination. The outer shell of the bead protects it from environmental contaminants and other conditions. When scientists are ready to run a PCR experiment, they simply rehydrate the lyobead with water or buffer, add their primers and DNA template, and are ready to obtain reliable and reproducible results.
Using lyobeads allows you to reduce production costs while enhancing product quality. Lyophilizing reagents as lyobeads stabilizes them, removing the need for cold storage and ensuring long-term shelf stability. This means lower manufacturing and transportation expenses, longer shelf life, and consistently high-quality results.
The Potential of Lyobead Technology
Sphera Discovery provides an efficient solution for lyophilizing your master mixes into lyobeads, without breaking the bank. Load your reagents, dispense droplets into a liquid nitrogen bath, and transfer them to a lyophilizer. With its compact design, Sphera Discovery fits on any lab bench and offers a fast production rate, making it ideal for labs of all sizes.
Experimenting with different dispensing and freezing methods allows you to fine-tune lyobead form factors. Partnering with BioDot can provide deeper insights into quality standards and customization options tailored to your needs. Start enhancing your lab’s efficiency with Sphera Discovery today!
About the Author
Wesley Thio is an Associate Product Marketing Manager at BioDot Inc. He obtained his B.S in Electrical and Computer Engineering at The Ohio State University and his M.S in Electrical and Computer Engineering at the University of Michigan. His research in chaotic circuits, battery technology, and AI accelerator hardware has led to over a dozen publications, multiple patents and co-authorship of the textbook Elegant Circuits: Simple Chaotic Oscillators. He received Ohio State’s Next Generation Innovator award in 2018.
